Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | DRD5 | P21918 | 5/20 | 0.47 |
| ▸ | HRH2 | P25021 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.47 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 3/20 | 0.47 |
| ▸ | HTR5A | P47898 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9140855 | 0.90 | MAPT (0.62) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9143010 | 0.89 | MAPT (0.56) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9142370 | 0.86 | KCNH2 (0.48) | DRD4DRD5HRH2HTR2AHTR7 | |
| SCHEMBL9139856 | 0.85 | MAPT (0.57) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9416405 | 0.85 | MAPT (0.57) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL8618083 | 0.85 | MAPT (0.63) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9145510 | 0.85 | MAPT (0.63) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9141175 | 0.85 | MAPT (0.63) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9144400 | 0.85 | MAPT (0.56) | MAPTDRD4DRD5HRH2HTR2A | |
| SCHEMBL9143712 | 0.85 | MAPT (0.56) | MAPTDRD4DRD5HRH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391552-A | Has strong antagonism against calcium with less side effects | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0612738-A1 | Diphenylpiperazine derivative and drug for circulatory organ containing the same | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1994-08-31 | — | — | EP | disclosed |
| EP-0549796-A1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEMICAL INDUSTRIES INC (JP) | 1993-07-07 | — | — | EP | disclosed |