Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.62 |
| ▸ | JAK3 | P52333 | 14/20 | 0.56 |
| ▸ | JAK2 | O60674 | 12/20 | 0.56 |
| ▸ | JAK1 | P23458 | 10/20 | 0.56 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914462 | 0.88 | SYK (0.66) | SYKJAK3JAK2JAK1STAT6 | |
| SCHEMBL913303 | 0.83 | SYK (0.59) | SYKJAK3JAK2JAK1STAT6 | |
| SCHEMBL762103 | 0.78 | SYK (0.93) | SYK | |
| SCHEMBL914287 | 0.77 | SYK (0.54) | SYKJAK3JAK2JAK1TYK2 | |
| SCHEMBL2627345 | 0.77 | SYK (0.76) | SYK | |
| SCHEMBL4711595 | 0.77 | SYK (0.76) | SYKJAK3JAK2JAK1 | |
| SCHEMBL761163 | 0.77 | SYK (1.00) | SYK | |
| SCHEMBL735946 | 0.76 | SYK (0.60) | SYK | |
| SCHEMBL736925 | 0.75 | SYK (0.60) | SYKJAK3JAK2JAK1 | |
| SCHEMBL4419303 | 0.74 | SYK (0.84) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853230-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130137673-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-8367689-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367689-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20110005947-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137673-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | SYK 72/4885JAK3 3/4885JAK2 2/4885 |
| US-20110005947-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | SYK 72/4885JAK3 3/4885JAK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.