Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 13/20 | 0.67 |
| ▸ | PRKACG | P22612 | 13/20 | 0.67 |
| ▸ | PRKACB | P22694 | 13/20 | 0.67 |
| ▸ | CDK4 | P11802 | 5/20 | 0.67 |
| ▸ | CCND1 | P24385 | 5/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.67 |
| ▸ | CDK2 | P24941 | 3/20 | 0.67 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.67 |
| ▸ | CDK1 | P06493 | 3/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.67 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | GSK3B | P49841 | 2/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | PRKCG | P05129 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9087155 | 0.95 | PRKACA (0.61) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL7815884 | 0.93 | PRKACA (0.67) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| Hydrochloric Acid SCHEMBL9083051 | 0.92 | PRKACA (0.66) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087353 | 0.91 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9082942 | 0.90 | PRKACA (0.68) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL7826095 | 0.90 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087395 | 0.90 | PRKACA (0.67) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9085996 | 0.90 | PRKACA (0.67) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087332 | 0.90 | PRKACA (0.67) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9085118 | 0.90 | PRKACA (0.67) | PRKACAPRKACGPRKACBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | disclosed |