⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9144363 | 0.84 | — | — | |
| SCHEMBL9144371 | 0.84 | — | — | |
| SCHEMBL9149503 | 0.82 | — | — | |
| SCHEMBL9148036 | 0.82 | — | — | |
| SCHEMBL9148044 | 0.82 | — | — | |
| SCHEMBL9145874 | 0.82 | — | — | |
| SCHEMBL9145889 | 0.82 | — | — | |
| SCHEMBL9149407 | 0.81 | — | — | |
| SCHEMBL9149416 | 0.81 | — | — | |
| SCHEMBL9324121 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387693-A | Intermediates for inhibitors of cholesterol biosynthesis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-02-07 | — | — | US | disclosed |
| US-5315012-A | Prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-24 | — | — | US | disclosed |
| US-5250561-A | Anticholesterool agents; prevention of hyperlipoproteinemia and atherosclerosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0529854-A2 | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-03-03 | — | — | EP | disclosed |