Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.38 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26451706 | 0.84 | CCR1 (0.40) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL27779093 | 0.79 | CCR1 (0.48) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL21632100 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL26450125 | 0.78 | FFAR1 (0.43) | SMN1; SMN2MEN1GAAKMT2ATSHR | |
| SCHEMBL11223803 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL27792007 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL10984015 | 0.76 | GAA (0.45) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL10632634 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CCR1MEN1GAAKMT2A | |
| SCHEMBL1343597 | 0.75 | ACP3 (0.44) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27925029 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2CCR1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416118-A | Enzyme inhibitors | SCHERING CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0583346-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992018462-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0508425-A1 | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |