Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150939 | 0.80 | CHRNA7 (0.40) | CHRNA7CHRNB4CHRNA3CHRM3CHRM2 | |
| SCHEMBL9718596 | 0.78 | KCNH2 (0.46) | — | |
| SCHEMBL9151124 | 0.76 | CHRNA7 (0.39) | CHRNA7CHRM2 | |
| SCHEMBL9154899 | 0.76 | CHRNA7 (0.54) | CHRNA7CHRM3CHRM2CHRM1CHRM4 | |
| Oxalic Acid SCHEMBL9154706 | 0.75 | CHRNA7 (0.37) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL9148174 | 0.74 | CHRNA7 (0.53) | CHRNA7CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL9148599 | 0.74 | CHRNA7 (0.49) | CHRNA7CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL9149299 | 0.72 | CHRNA7 (0.50) | CHRNA7CHRM3CHRM2CHRM1CHRM4 | |
| Oxalic Acid SCHEMBL9151906 | 0.72 | CHRNA7 (0.47) | CHRNA7CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL10521021 | 0.71 | CHRNA7 (0.44) | CHRNA7CHRNB4CHRNA3CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | claimed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | claimed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | claimed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |