Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.37 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.37 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153486 | 1.00 | USP2 (0.48) | USP2HSD17B10SPHK1HTTTSHR | |
| SCHEMBL12587483 | 1.00 | USP2 (0.48) | USP2HSD17B10SPHK1HTTTSHR | |
| SCHEMBL9152360 | 1.00 | USP2 (0.48) | USP2HSD17B10SPHK1HTTTSHR | |
| SCHEMBL9153536 | 0.93 | USP2 (0.57) | USP2HSD17B10SPHK1HTTLPAR5 | |
| SCHEMBL9154073 | 0.91 | USP2 (0.60) | USP2HSD17B10SPHK1HTTLPAR5 | |
| SCHEMBL9154669 | 0.91 | USP2 (0.60) | USP2HSD17B10SPHK1HTTLPAR5 | |
| SCHEMBL9152943 | 0.91 | USP2 (0.60) | USP2HSD17B10SPHK1HTTLPAR5 | |
| SCHEMBL9149880 | 0.91 | USP2 (0.60) | USP2HSD17B10SPHK1HTTLPAR5 | |
| SCHEMBL9156384 | 0.91 | USP2 (0.60) | USP2HSD17B10SPHK1HTTLPAR5 | |
| SCHEMBL9152331 | 0.91 | USP2 (0.60) | USP2HSD17B10SPHK1HTTLPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8329742-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| US-7915306-B2 | For therapy of inflammatory or autoimmune disorders | EISAI CO., LTD. (JP) | 2011-03-29 | — | — | US | disclosed |
| US-7799827-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2010-09-21 | — | — | US | disclosed |
| EP-0351782-B1 | Optically active compounds liquid crystal composition containing said compound, and liquid crystal optical modulator using said composition | HITACHI LTD (JP) | 1995-01-04 | — | — | EP | disclosed |
| US-5328643-A | Electrooptic display, switches, modulators; physical and chemical stability and spontaneous polarization | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| EP-0351782-A2 | Optically active compounds liquid crystal composition containing said compound, and liquid crystal optical modulator using said composition | HITACHI, LTD. (JP) | 1990-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT1, TBXA2R, VEGFA | USP2 4728/4885HSD17B10 2919/4885SPHK1 847/4885 |
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT4, VEGFA, FLT1 | USP2 4538/4885HSD17B10 2338/4885SPHK1 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.