SCHEMBL9157435

SCHEMBL9157435

COC=C(C(=O)OC)N(C)c1cc(-c2ccc(C(F)F)cc2)ncn1

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.33
CLK4 Q9HAZ1 4/20 0.33
ALDH1A1 P00352 3/20 0.33
HSD17B10 Q99714 3/20 0.33
CYP3A4 P08684 2/20 0.32
CYP2D6 P10635 2/20 0.32
USP2 O75604 1/20 0.32
CYP2C9 P11712 1/20 0.32
TRPA1 O75762 2/20 0.31
KMO O15229 1/20 0.31
TP53 P04637 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31
KMT2A Q03164 1/20 0.30
FAAH O00519 1/20 0.30
PIK3CA P42336 1/20 0.30
SLC34A1 Q06495 1/20 0.30
CDK9 P50750 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9472128 0.79 CYP1A2 (0.48) CYP1A2CLK4ALDH1A1HSD17B10CYP3A4
SCHEMBL9031392 0.79 CYP1A2 (0.48) CYP1A2CLK4ALDH1A1HSD17B10CYP3A4
SCHEMBL9472132 0.70 CYP1A2 (0.50) CYP1A2CLK4ALDH1A1HSD17B10CYP3A4
SCHEMBL9469431 0.68 CYP1A2 (0.48) CYP1A2CLK4ALDH1A1HSD17B10CYP3A4
SCHEMBL9031121 0.68 CYP1A2 (0.48) CYP1A2CLK4ALDH1A1HSD17B10CYP3A4
SCHEMBL9399353 0.67 USP30 (0.43) ALDH1A1HSD17B10KMT2A
SCHEMBL7527226 0.67 USP30 (0.43) ALDH1A1HSD17B10KMT2A
SCHEMBL9865578 0.67 CNR1 (0.45)
SCHEMBL8737258 0.67 CNR1 (0.45)
SCHEMBL9163369 0.67 CNR1 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5434267-A Process for the preparation of substituted 3-alkoxyacrylates BAYER AKTIENGESELLSCHAFT (DE) 1995-07-18 US disclosed