SCHEMBL9158646

SCHEMBL9158646

CCCCCC1CCC(c2ccc(-c3ccc(F)nc3F)c(F)c2)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.37
GAA P10253 3/20 0.37
MEN1 O00255 5/20 0.34
KMT2A Q03164 5/20 0.34
CYP2C9 P11712 2/20 0.34
MAPK1 P28482 3/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
NPC1 O15118 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
SPHK1 Q9NYA1 3/20 0.32
ACP1 P24666 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2C8 P10632 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9158643 1.00 MAPT (0.37) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9156409 0.99 MAPT (0.39) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9156400 0.99 MAPT (0.39) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9153733 0.96 MEN1 (0.35) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9153725 0.96 MEN1 (0.35) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9766658 0.94 CYP2C9 (0.38) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9766653 0.94 CYP2C9 (0.38) MAPTGAAMEN1KMT2ACYP2C9
SCHEMBL9158477 0.92 CYP2C9 (0.41) MAPTMEN1KMT2ACYP2C9MAPK1
SCHEMBL9158483 0.92 CYP2C9 (0.41) MAPTMEN1KMT2ACYP2C9MAPK1
SCHEMBL11117883 0.89 CYP2C9 (0.40) MAPTGAAMEN1KMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0445248-B1 PYRIDINE DERIVATIVES MERCK PATENT GMBH (DE) 1995-03-08 EP disclosed
US-5205962-A Stable liquid crystals MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-04-27 US disclosed
EP-0445248-A1 PYRIDINE DERIVATIVES. MERCK PATENT GMBH (DE) 1991-09-11 EP disclosed
WO-1991004248-A1 PYRIDINE DERIVATIVES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1991-04-04 WO disclosed