Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924536 | 1.00 | HTT (0.55) | HTTPKMCNR2ALDH1A1KMT2A | |
| SCHEMBL5924407 | 0.98 | HTT (0.53) | HTTPKMCNR2ALDH1A1KMT2A | |
| SCHEMBL2955197 | 0.88 | HTT (0.58) | HTTPKMCNR2ALDH1A1KMT2A | |
| SCHEMBL9064272 | 0.88 | HTT (0.58) | HTTPKMCNR2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL2954100 | 0.86 | HTT (0.57) | HTTPKMCNR2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL2954104 | 0.86 | HTT (0.57) | HTTPKMCNR2ALDH1A1KMT2A | |
| SCHEMBL2952902 | 0.86 | HTT (0.56) | HTTPKMCNR2ALDH1A1KMT2A | |
| SCHEMBL9158266 | 0.85 | SMN1; SMN2 (0.58) | HTTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5924570 | 0.85 | CYP2D6 (0.58) | ALDH1A1KMT2ALMNAHDAC8HDAC6 | |
| SCHEMBL13575472 | 0.80 | HTT (0.50) | HTTALDH1A1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476849-A | Inhibiting advanced glycosylation and/or crosslinking of target protein | THE ROCKEFELLER UNIVERSITY (US) | 1995-12-19 | — | — | US | disclosed |