Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887008 | 0.89 | PTGER1 (0.72) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9169823 | 0.88 | PTGER1 (0.52) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9175548 | 0.86 | PTGER1 (0.51) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9167824 | 0.86 | PTGER1 (0.53) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9170896 | 0.86 | PTGER1 (0.53) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9172765 | 0.85 | PTGER1 (0.50) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9173178 | 0.85 | PTGER1 (0.49) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9174933 | 0.85 | PTGER1 (0.49) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8887104 | 0.83 | PTGER1 (0.69) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9157050 | 0.83 | MAPT (0.61) | PTGER1MAPTMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995033733-A1 | SUBSTITUTED DIBENZOXAZEPINE AND DIBENZOTHIAZEPINE UREAS USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | claimed |
| US-5449675-A | Analgesics | G. D. SEARLE & CO. (US) | 1995-09-12 | — | — | US | disclosed |