SCHEMBL9160064

SCHEMBL9160064

COc1ccc(CCN(C)CC(C)CCl)cc1OC

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.68
CYP1A2 P05177 3/20 0.68
CYP2D6 P10635 3/20 0.68
BLM P54132 2/20 0.66
PMP22 Q01453 2/20 0.66
AOC3 Q16853 1/20 0.56
KDM4E B2RXH2 4/20 0.55
ALDH1A1 P00352 3/20 0.55
SMN1; SMN2 Q16637 2/20 0.54
MEN1 O00255 5/20 0.52
KMT2A Q03164 5/20 0.52
SMPD1 P17405 2/20 0.51
CYP2C9 P11712 2/20 0.50
ABCB1 P08183 3/20 0.48
ABCC1 P33527 3/20 0.48
CYP2C19 P33261 2/20 0.48
ABCB11 O95342 2/20 0.48
KCNH2 Q12809 2/20 0.48
TSHR P16473 2/20 0.48
LMNA P02545 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9264551 1.00 CYP3A4 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9269718 1.00 CYP3A4 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL27311591 0.99 PMP22 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
Hydrochloric Acid SCHEMBL9574595 0.99 PMP22 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
Ethyl Acetate SCHEMBL9271914 0.87 PMP22 (0.53) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL8828369 0.86 CYP3A4 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9263255 0.86 CYP3A4 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9262392 0.86 CYP3A4 (0.68) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9212854 0.85 CYP3A4 (0.76) CYP3A4CYP1A2CYP2D6BLMPMP22
SCHEMBL9157545 0.84 CYP3A4 (0.64) CYP3A4CYP1A2CYP2D6BLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1031754-C Dithiane HOFFMANN LA ROCHE (CH) 1996-05-08 CN disclosed
US-5430059-A Treating heart disease EISAI CO., LTD. (JP) 1995-07-04 US disclosed
US-5405866-A Administering with cytostatic drugs to treat drug resistant tumors HOFFMANN-LA ROCHE INC. (US) 1995-04-11 US disclosed
EP-0399358-B1 Butenoic acid derivatives EISAI CO LTD (JP) 1995-03-08 EP disclosed
EP-0633248-A1 Butenoic acid derivatives Eisai Co., Ltd. (JP) 1995-01-11 EP disclosed
US-5302727-A For use with antitumor agents HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
EP-0589491-A1 Butenoic acid derivatives Eisai Co., Ltd. (JP) 1994-03-30 EP disclosed
US-5292770-A Butenoic acid derivatives EISAI CO., LTD. (JP) 1994-03-08 US disclosed
CN-1068569-A DITHIANE HOFFMANN LA ROCHE (CH) 1993-02-03 CN disclosed
EP-0523493-A1 Dithianes F. HOFFMANN-LA ROCHE AG (CH) 1993-01-20 EP disclosed
US-5166188-A Cardiovascular disorders, antiischemic agents EISAI CO., LTD. (JP) 1992-11-24 US disclosed
EP-0399358-A2 Butenoic acid derivatives Eisai Co., Ltd. (JP) 1990-11-28 EP disclosed
US-4127588-A Sulphur containing derivatives HOFFMANN-LA ROCHE INC. (US) 1978-11-28 US disclosed
US-4073797-A CORONARY DILATOR HOFFMANN-LA ROCHE INC. (US) 1978-02-14 US disclosed
US-4003914-A DITHIANE AND DISULFONE CORONARY DILATING AGENTS HOFFMANN-LA ROCHE INC. (US) 1977-01-18 US disclosed