SCHEMBL9160091

SCHEMBL9160091

COC(=O)NCCOc1ccc(Oc2cc(F)cc(F)c2)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 14/20 0.49
PPARD Q03181 10/20 0.48
PPARG P37231 5/20 0.48
LMNA P02545 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.43
HPGD P15428 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9161080 0.90 PPARA (0.47) PPARAPPARDPPARGALDH1A1NPC1
SCHEMBL9302626 0.89 PPARA (0.49) PPARAPPARDPPARGLMNAALDH1A1
SCHEMBL9157535 0.88 PPARA (0.47) PPARAPPARDPPARGLMNAHPGD
SCHEMBL9162070 0.88 PPARA (0.51) PPARAPPARDPPARGALDH1A1NPC1
SCHEMBL9162089 0.88 PPARA (0.44) PPARAPPARDPPARGALDH1A1NPC1
SCHEMBL9281638 0.87 PPARA (0.48) PPARAPPARDPPARGLMNAALDH1A1
SCHEMBL9158270 0.87 PPARA (0.46) PPARAPPARDPPARGALDH1A1NPC1
SCHEMBL9280075 0.86 PPARA (0.44) PPARAPPARDPPARG
SCHEMBL9157637 0.86 PPARA (0.47) PPARAPPARDPPARGALDH1A1NPC1
SCHEMBL9163268 0.86 PPARA (0.43) PPARAPPARDPPARGALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0460472-B1 Carbamic acid derivatives, their production and use SUMITOMO CHEMICAL CO (JP) 1995-03-08 EP claimed
US-5346920-A Insecticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-09-13 US claimed
EP-0460472-B1 Carbamic acid derivatives, their production and use SUMITOMO CHEMICAL CO (JP) 1995-03-08 EP disclosed
US-5346920-A Insecticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-09-13 US disclosed
EP-0460472-A1 Carbamic acid derivatives, their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-12-11 EP disclosed