Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norethindrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 5/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.98 |
| ▸ | LMNA | P02545 | 5/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.98 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.98 |
| ▸ | ESR1 | P03372 | 2/20 | 0.98 |
| ▸ | SHBG | P04278 | 2/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.72 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.72 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.72 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | AR | P10275 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norethindrone SCHEMBL5021649 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL14577661 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL19510084 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL14074493 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL7768886 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL24476231 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL6834811 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL11781372 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL23390 | 0.99 | CYP3A4 (1.00) | CYP3A4LMNAPGRABCB11CYP2C19 | |
| Norethindrone SCHEMBL11291575 | 0.96 | CYP3A4 (0.94) | CYP3A4LMNAPGRABCB11CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116507327-A | Chewable formulations | 礼蓝动物保健有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-111032024-A | Bioerodible drug delivery implant | 赫拉健康解决方案公司 | 2020-04-17 | — | — | CN | disclosed |
| US-5387421-A | Plug releaseable upon application of pressure from inner chamber | TSRL, INC. (US) | 1995-02-07 | — | — | US | disclosed |