Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9161601 | 1.00 | KDM4E (0.67) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL9390972 | 1.00 | KDM4E (0.67) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL22711519 | 0.80 | KDM4E (0.67) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL7372983 | 0.80 | KDM4E (1.00) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL1591865 | 0.75 | KDM4E (0.65) | KDM4EHTTCYP2A13TDP1LMNA | |
| SCHEMBL70870 | 0.75 | KDM4E (0.65) | KDM4EHTTCYP2A13TDP1LMNA | |
| SCHEMBL4510409 | 0.75 | KDM4E (0.65) | KDM4EHTTCYP2A13TDP1LMNA | |
| SCHEMBL1591329 | 0.75 | KDM4E (0.65) | KDM4EHTTCYP2A13TDP1LMNA | |
| SCHEMBL31193156 | 0.75 | KDM4E (0.60) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL13850015 | 0.74 | CYP2A13 (1.00) | KDM4EHTTCYP2A13TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5382666-A | Heterocyclic intermediates | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-01-17 | — | — | US | disclosed |
| WO-1994015926-A1 | ANGIOTENSIN II INHIBITORS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-07-21 | — | — | WO | disclosed |
| US-5256658-A | Biphenylyl tetrazoles for hypertension in mammals | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |