Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SHBG | P04278 | 1/20 | 0.32 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.32 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178008 | 0.90 | POLB (0.48) | MAPTPOLBPGRCYP19A1CYP3A4 | |
| SCHEMBL8653911 | 0.90 | MAPT (0.48) | MAPTPOLBPGRARCYP19A1 | |
| SCHEMBL9177360 | 0.88 | POLB (0.46) | MAPTPOLBCYP19A1CYP3A4CYP2C9 | |
| SCHEMBL8653835 | 0.88 | MAPT (0.46) | MAPTPOLBPGRCYP19A1CYP3A4 | |
| SCHEMBL9178326 | 0.87 | POLB (0.46) | MAPTPOLBPGRCYP19A1CYP3A4 | |
| SCHEMBL9174332 | 0.85 | MAPT (0.44) | MAPTPOLBPGRARCYP19A1 | |
| SCHEMBL9356383 | 0.85 | POLB (0.44) | MAPTPOLBPGRCYP19A1CYP3A4 | |
| SCHEMBL9179142 | 0.85 | POLB (0.44) | MAPTPOLBPGRCYP19A1CYP3A4 | |
| SCHEMBL9174016 | 0.83 | MAPT (0.42) | MAPTPOLBPGRARCYP19A1 | |
| SCHEMBL8654083 | 0.83 | MAPT (0.42) | MAPTPOLBCYP19A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405979-A | Stereoselectively reducing phenyl-substituted estradiene with electropositive metal in electron-solvating solvent, cleaving ketone protective group with acid | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |
| EP-0532562-B1 | PROCESS FOR PRODUCING 10$g(b)-H-STEROIDS | SCHERING AG (DE) | 1994-11-23 | — | — | EP | disclosed |