Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 19/20 | 0.86 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9173601 | 0.92 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9305628 | 0.91 | ALOX5AP (0.87) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9178524 | 0.89 | ALOX5AP (0.71) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL9447569 | 0.89 | ALOX5AP (0.87) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9315369 | 0.85 | ALOX5AP (0.86) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL9044184 | 0.84 | PTGES2 (0.78) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL9185735 | 0.84 | ALOX5AP (0.86) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9305053 | 0.84 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9387952 | 0.83 | ALOX5AP (0.88) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9388776 | 0.83 | ALOX5AP (0.87) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389650-A | Antiinflammatory agents, anticoagulants, antispasmodic agents | MERCK FROSST CANADA, INC. (CA) | 1995-02-14 | — | — | US | disclosed |
| WO-1994013662-A1 | (AZAARYLMETHOXY)INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |