Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721972 | 0.87 | TOP2A (0.55) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL4307487 | 0.86 | TOP2A (0.54) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL4303871 | 0.84 | TOP2A (0.50) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL27379841 | 0.83 | TOP2A (0.51) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL205455 | 0.80 | TOP2A (0.66) | TOP2AKDM4EALDH1A1HPGDATM | |
| SCHEMBL1271524 | 0.80 | SMN1; SMN2 (0.49) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL1398896 | 0.80 | TOP2A (0.59) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7440762 | 0.79 | TOP2A (0.55) | TOP2AKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL12900291 | 0.79 | TOP2A (0.47) | TOP2AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL9270249 | 0.78 | ELANE (0.40) | TOP2AKDM4EHPGDATMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5440046-A | Angiotensin antagonist, hypotensive agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| US-5350751-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-27 | — | — | US | disclosed |