Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186123 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL28550674 | 0.95 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL26077281 | 0.95 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL28546986 | 0.95 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL523499 | 0.92 | PDE4B (0.54) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL523841 | 0.92 | PDE4B (0.54) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL3547026 | 0.92 | PDE4B (0.54) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL12527110 | 0.92 | PDE4B (0.54) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL523500 | 0.92 | PDE4B (0.54) | SMN1; SMN2NPC1RAB9APDE4BHTT | |
| SCHEMBL30965777 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413455-B1 | Azabicyclo quinolone carboxylic acids | PFIZER (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5391763-A | 3-aza-bicyclo[3.1.0]hexanes which are intermediates for anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1995-02-21 | — | — | US | disclosed |
| US-5229396-A | Anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0413455-A2 | Azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1991-02-20 | — | — | EP | disclosed |