Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BID | P55957 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL9184746 | 1.00 | BID (0.48) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9182392 | 0.87 | BID (0.51) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9182404 | 0.87 | BID (0.51) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9186310 | 0.87 | BID (0.51) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9182382 | 0.87 | BID (0.51) | BIDBCL2L1MCL1BAK1MAPT | |
| Lithium SCHEMBL9184756 | 0.86 | BID (0.50) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9184743 | 0.86 | BID (0.50) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9184749 | 0.86 | BID (0.50) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9188022 | 0.86 | BID (0.50) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL9182720 | 0.86 | BID (0.50) | BIDBCL2L1MCL1BAK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541706-B1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1995-09-13 | — | — | EP | claimed |
| EP-0541706-A4 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS | — | 1993-12-01 | — | — | EP | claimed |
| EP-0541706-A1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS. | SMITHKLINE BEECHAM CORP (US) | 1993-05-19 | — | — | EP | claimed |
| WO-1992002519-A1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | claimed |
| EP-0541706-B1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1995-09-13 | — | — | EP | disclosed |
| EP-0541706-A4 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS | — | 1993-12-01 | — | — | EP | disclosed |
| EP-0541706-A1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS. | SMITHKLINE BEECHAM CORP (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992003462-A1 | NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PREPARATION AND THEIR USE AS ANTIVIRAL DRUGS | BOEHRINGER MANNHEIM GMBH (DE) | 1992-03-05 | — | — | WO | disclosed |
| WO-1992002519-A1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF 2-HYDROXY-3-SULFIDO-3-PHENYL PROPANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |