Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9191682 | 0.85 | CYP19A1 (0.62) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL10477336 | 0.84 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL9235863 | 0.80 | CYP19A1 (0.55) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL9190551 | 0.75 | CYP19A1 (0.50) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL9193057 | 0.74 | TDP1 (0.44) | MEN1ALDH1A1HSP90AA1CYP3A4MAPT | |
| SCHEMBL9194817 | 0.74 | CYP17A1 (0.50) | CYP19A1CYP11B1CYP11B2CYP17A1CYP3A4 | |
| SCHEMBL9198545 | 0.73 | CYP17A1 (0.52) | CYP19A1CYP17A1TSHRADRB2 | |
| SCHEMBL9192600 | 0.73 | CYP17A1 (0.52) | CYP19A1CYP17A1MEN1ALDH1A1CYP3A4 | |
| SCHEMBL9523782 | 0.72 | CYP19A1 (0.60) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL11461900 | 0.71 | CYP11B1 (0.48) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371564-B1 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-07-12 | — | — | EP | disclosed |
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |