Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10550960 | 0.82 | — | — | |
| SCHEMBL9483357 | 0.76 | HSP90AA1 (0.39) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL9194438 | 0.74 | ATM (0.33) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL6468496 | 0.70 | NT5E (0.42) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL7804841 | 0.68 | POLB (0.35) | KDM4EHSP90AA1HSP90AB1ALDH1A1HSD17B10 | |
| SCHEMBL3293782 | 0.67 | HSP90AA1 (0.43) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL10271825 | 0.65 | HSP90AA1 (0.52) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL1257925 | 0.65 | HSP90AA1 (0.41) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL17049131 | 0.65 | HSP90AA1 (0.41) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 | |
| SCHEMBL1965945 | 0.65 | KDM4E (0.46) | KDM4EHSP90AA1HSP90AB1NT5EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445644-B1 | Trifluoro- respectively chlorodifluoromethoxy pyrimidines and process for their preparation | BASF AG (DE) | 1995-05-24 | — | — | EP | disclosed |
| US-5237063-A | TRIFLUORO- AND CHLORODIFLUOROMETHOXYPYRIMIDINES AND THE PREPARATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 1993-08-17 | — | — | US | disclosed |
| EP-0445644-A1 | Trifluoro- respectively chlorodifluoromethoxy pyrimidines and process for their preparation | BASF Aktiengesellschaft (DE) | 1991-09-11 | — | — | EP | disclosed |