Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.54 |
| ▸ | RARG | P13631 | 9/20 | 0.54 |
| ▸ | RARA | P10276 | 8/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196746 | 1.00 | RARB (0.54) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9142983 | 0.95 | RARB (0.56) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9142979 | 0.95 | RARB (0.56) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9148441 | 0.88 | RARB (0.52) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9148433 | 0.88 | RARB (0.52) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9145537 | 0.87 | RARG (0.48) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9145541 | 0.87 | RARG (0.48) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9144382 | 0.87 | RARB (0.51) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9144389 | 0.87 | RARB (0.51) | RARBRARGRARARXRAHPGD | |
| SCHEMBL9143264 | 0.86 | RARB (0.53) | RARBRARGRARARXRAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350846-B1 | Condensed heterocyclic compounds and their use in therapy | HOFFMANN LA ROCHE (CH) | 1995-10-11 | — | — | EP | claimed |
| US-5037825-A | Useful In The Treatment Of Neoplasms, Dermatoses And Aging Of The Skin | HOFFMANN-LA ROCHE INC. (US) | 1991-08-06 | — | — | US | claimed |