Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207784 | 0.84 | GRIN2D (0.46) | CYP1A2POLBCYP3A4CYP2C9TSHR | |
| SCHEMBL9208399 | 0.77 | GRIN2D (0.48) | CYP1A2POLBCYP3A4CYP2C9TSHR | |
| SCHEMBL9197705 | 0.76 | CYP1A2 (0.51) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL9203205 | 0.76 | GRIN2D (0.51) | CYP1A2MEN1CYP2D6KMT2APOLB | |
| SCHEMBL9204683 | 0.75 | GRIN2D (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL1612505 | 0.73 | KDM4E (0.79) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL9206035 | 0.72 | GRIN2D (0.56) | CYP1A2MEN1CYP2D6KMT2ACYP3A4 | |
| SCHEMBL9199502 | 0.71 | GRIN2D (0.46) | CYP1A2POLBCYP3A4CYP2C9TSHR | |
| SCHEMBL8783905 | 0.69 | CYP1A2 (0.58) | CYP1A2KDM4EMEN1CYP2D6CYP2C19 | |
| SCHEMBL9202917 | 0.69 | GRIN2D (0.55) | CYP1A2MEN1CYP2D6KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489458-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1995-06-07 | — | — | EP | claimed |
| EP-0489458-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-06-10 | — | — | EP | claimed |
| EP-0489458-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1995-06-07 | — | — | EP | disclosed |
| US-5252584-A | Antagonist for treating nervous system disorders | MERCK SHARP & DOHME LIMITED (GB) | 1993-10-12 | — | — | US | disclosed |
| EP-0489458-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-06-10 | — | — | EP | disclosed |