Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 10/20 | 0.77 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.77 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.77 |
| ▸ | NMBR | P28336 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641246 | 0.99 | SOAT1 (0.76) | SOAT1SOAT2ACAT1NMBRLMNA | |
| Hydrochloric Acid SCHEMBL20591099 | 0.99 | SOAT1 (0.76) | SOAT1SOAT2ACAT1NMBRLMNA | |
| SCHEMBL9818653 | 0.97 | SOAT1 (0.73) | SOAT1SOAT2ACAT1NMBRLMNA | |
| SCHEMBL9818696 | 0.95 | SOAT1 (0.69) | SOAT1SOAT2ACAT1NMBR | |
| SCHEMBL9640319 | 0.93 | SOAT1 (0.68) | SOAT1SOAT2ACAT1NMBRLMNA | |
| SCHEMBL9640371 | 0.92 | SOAT1 (0.67) | SOAT1SOAT2ACAT1NMBRLMNA | |
| SCHEMBL9641191 | 0.92 | SOAT1 (0.67) | SOAT1SOAT2ACAT1NMBRLMNA | |
| SCHEMBL9640381 | 0.91 | SOAT1 (0.66) | SOAT1SOAT2ACAT1NMBRLMNA | |
| SCHEMBL9818681 | 0.91 | SOAT1 (0.71) | SOAT1SOAT2ACAT1NMBR | |
| SCHEMBL9818674 | 0.90 | SOAT1 (0.78) | SOAT1SOAT2ACAT1NMBRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0500348-B1 | Disubstituted ureas and thioureas | PHARMACIA SPA (IT) | 1995-05-17 | — | — | EP | disclosed |
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | disclosed |
| US-5015644-A | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds | WARNER-LAMBERT COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0293880-A1 | Antihyperlipidemic and antiatherosclerotic urea compounds | WARNER-LAMBERT COMPANY (US) | 1988-12-07 | — | — | EP | disclosed |