Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | C1R | P00736 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775894 | 0.81 | S1PR1 (0.40) | AKR1B1L3MBTL1TDP1S1PR1 | |
| SCHEMBL12072153 | 0.80 | NPC1 (0.57) | L3MBTL1MAPK1CHUKTXNRD1NOX4 | |
| SCHEMBL9674957 | 0.78 | NPC1 (0.56) | AKR1B1NOTUML3MBTL1MAPK1CHUK | |
| SCHEMBL19875492 | 0.74 | AKR1B1 (0.48) | AKR1B1NOTUMPPARGPPARDPPARA | |
| SCHEMBL18039135 | 0.73 | C1R (0.46) | AKR1B1NOTUMC1RPSMB8L3MBTL1 | |
| SCHEMBL30566770 | 0.73 | AKR1B1 (0.48) | AKR1B1NOTUMMAPK1TDP1S1PR1 | |
| SCHEMBL10094561 | 0.73 | NOTUM (0.45) | AKR1B1NOTUMPPARGPPARDPPARA | |
| SCHEMBL30063213 | 0.73 | C1R (0.46) | AKR1B1NOTUMC1RPSMB8L3MBTL1 | |
| SCHEMBL28494497 | 0.73 | NOTUM (0.49) | NOTUMC1RPSMB8MAPK1TDP1 | |
| SCHEMBL9675049 | 0.73 | AKR1B1 (0.48) | AKR1B1NOTUMMAPK1TDP1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401981-B1 | Pyridazinone deriratives | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| US-4996204-A | Antidiabetic agents | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0401981-A1 | Pyridazinone deriratives | PFIZER INC. (US) | 1990-12-12 | — | — | EP | disclosed |