SCHEMBL9205380

SCHEMBL9205380

COC(=O)Cn1c(CBr)cccc1=O

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
ALDH1A1 P00352 3/20 0.46
HSD17B10 Q99714 3/20 0.46
TSHR P16473 1/20 0.41
KMT2A Q03164 2/20 0.41
GAA P10253 2/20 0.41
MEN1 O00255 1/20 0.41
GLA P06280 1/20 0.41
RCE1 Q9Y256 1/20 0.41
CDK4 P11802 1/20 0.41
CCND1 P24385 1/20 0.41
CCND2 P30279 1/20 0.41
CCND3 P30281 1/20 0.41
POLB P06746 1/20 0.40
IDH1 O75874 1/20 0.39
KAT2B Q92831 1/20 0.38
NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29959857 0.81 KDM4E (0.54) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL9207480 0.79 KDM4E (0.56) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL22114352 0.78 KDM4E (0.54) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL23923170 0.77 KDM4E (0.47) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL9202399 0.74 KMT2A (0.45) KDM4ESMN1; SMN2ALDH1A1HSD17B10KMT2A
SCHEMBL9609789 0.72 KDM4E (0.39) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL23922794 0.71 KDM4E (0.47) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL6930024 0.70 KDM4E (0.49) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL9611241 0.70 KDM4E (0.37) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR
SCHEMBL11811656 0.68 KDM4E (0.80) KDM4ESMN1; SMN2ALDH1A1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0535980-B1 2-Pyridone derivatives, a process for their preparation and their use as fungicides SUMITOMO CHEMICAL CO (JP) 1995-12-20 EP disclosed
US-5322845-A Controlling plant diseases SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-06-21 US disclosed
EP-0535980-A1 2-Pyridone derivatives, a process for their preparation and their use as fungicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-04-07 EP disclosed