Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.46 |
| ▸ | PDE4A | P27815 | 13/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145603 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL145246 | 0.86 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL7798497 | 0.85 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL143077 | 0.84 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL144579 | 0.83 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL143950 | 0.82 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL145168 | 0.80 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL143070 | 0.80 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL143952 | 0.77 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL6842626 | 0.77 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539806-B1 | Thiadiazinones and medicines containing them, having in particular a positive inotropic and vasodilating activity | MERCK PATENT GMBH (DE) | 1995-01-04 | — | — | EP | disclosed |
| US-5276027-A | Thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0539806-A1 | Thiadiazinones and medicines containing them, having in particular a positive inotropic and vasodilating activity | MERCK PATENT GmbH (DE) | 1993-05-05 | — | — | EP | disclosed |