Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 3/20 | 0.44 |
| ▸ | DTYMK | P23919 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206967 | 1.00 | TSHR (0.44) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL7594797 | 0.88 | TSHR (0.44) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL16737176 | 0.84 | TSHR (0.42) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL28910119 | 0.84 | TSHR (0.46) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL5925550 | 0.83 | DTYMK (0.47) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL6214961 | 0.83 | TSHR (0.57) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL23539368 | 0.81 | TSHR (0.44) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL20651994 | 0.81 | TSHR (0.44) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL6212344 | 0.80 | TSHR (0.43) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL7712104 | 0.79 | TSHR (0.45) | TSHRALDH1A1TDP1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459561-B1 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5268378-A | Oxo group in 2 and 4 position | MERCK SHARP & DOHME, LIMITED (GB) | 1993-12-07 | — | — | US | disclosed |
| EP-0459561-A2 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |