Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.70 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | KDM1A | O60341 | 5/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | RPA1 | P27694 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22892018 | 0.89 | CA9 (0.58) | CHRNA7CA9KDM1ARPA1FAAH | |
| SCHEMBL5148820 | 0.88 | CA9 (0.57) | CHRNA7CA9KDM1ARPA1FAAH | |
| SCHEMBL9203679 | 0.88 | CHRNA7 (0.77) | CHRNA7CA9PTGS2MEN1KMT2A | |
| SCHEMBL8922991 | 0.88 | CA9 (0.56) | CHRNA7CA9KDM1ARPA1FAAH | |
| SCHEMBL20820101 | 0.88 | KDM1A (0.57) | CHRNA7CA9KDM1ARPA1FAAH | |
| SCHEMBL20820086 | 0.86 | KDM1A (0.60) | CHRNA7CA9KDM1AFAAH | |
| SCHEMBL9206474 | 0.86 | CHRNA7 (0.77) | CHRNA7CA9PTGS2RPA1MEN1 | |
| SCHEMBL9203093 | 0.85 | CHRNA7 (0.72) | CHRNA7CA9PTGS2MEN1KMT2A | |
| SCHEMBL9212244 | 0.85 | CHRNA7 (0.72) | CHRNA7CA9PTGS2RPA1MEN1 | |
| SCHEMBL9202688 | 0.84 | CHRNA7 (0.71) | CHRNA7CA9PTGS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |