Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201128 | 0.85 | NPC1 (0.49) | NPC1RAB9ACA12CA9MAPT | |
| SCHEMBL11489222 | 0.84 | CA12 (0.52) | NPC1RAB9ACA12CA9KDM4E | |
| SCHEMBL7615738 | 0.83 | MAOB (0.56) | NPC1RAB9ACA12CA9KDM4E | |
| SCHEMBL9209466 | 0.82 | MAOB (0.60) | NPC1RAB9ACA12CA9KDM4E | |
| SCHEMBL9207445 | 0.80 | CA12 (0.58) | NPC1RAB9ACA12CA9KDM4E | |
| SCHEMBL9528707 | 0.77 | CA12 (0.47) | CA12CA9KDM4ETP53MAPT | |
| SCHEMBL8439032 | 0.77 | NPC1 (0.53) | NPC1RAB9ACA12CA9KDM4E | |
| SCHEMBL7616879 | 0.77 | CA12 (0.61) | CA12CA9KDM4ETP53MAPT | |
| SCHEMBL9202075 | 0.75 | NQO1 (0.53) | NPC1RAB9ACA12CA9MAOB | |
| SCHEMBL30739584 | 0.74 | GAA (0.58) | NPC1RAB9ATP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3991204-A | Method of using benzopyrans as antiparasitic agents | AMERICAN CYANAMID COMPANY (US) | 1976-11-09 | — | — | US | claimed |
| EP-0550493-B1 | ANTHELMINTIC AND ANTICOCCIDAL 3-CARBAMOYL-4-HYDROXYCOUMARINS, METHOD OF USE AND COMPOSITIONS | UPJOHN CO (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1992006083-A1 | ANTHELMINTIC AND ANTICOCCIDAL 3-CARBAMOYL-4-HYDROXYCOUMARINS, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1992-04-16 | — | — | WO | disclosed |