Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | IL6ST | P40189 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 2/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11359456 | 0.90 | PADI4 (0.56) | POLBPADI4MEN1KMT2ACYP19A1 | |
| SCHEMBL3449953 | 0.86 | POLB (0.63) | POLBPADI4IL6STCDC25AICMT | |
| SCHEMBL8126918 | 0.85 | CDC25A (0.64) | POLBIL6STCDC25AICMT | |
| SCHEMBL5469549 | 0.84 | CYP19A1 (0.59) | POLBPADI4MEN1KMT2ACYP19A1 | |
| SCHEMBL12558479 | 0.83 | PADI4 (0.55) | POLBPADI4MEN1KMT2ACYP19A1 | |
| Ammonia Solution, Strong SCHEMBL15466974 | 0.81 | PADI4 (0.53) | POLBPADI4MEN1KMT2ACYP19A1 | |
| SCHEMBL9209850 | 0.81 | POLB (1.00) | POLBPADI4KMT2ACYP19A1HTR6 | |
| SCHEMBL11623320 | 0.81 | POLB (0.57) | POLBPADI4IL6STCDC25AHTR6 | |
| SCHEMBL4535061 | 0.80 | HTR2A (0.65) | PADI4MEN1KMT2ACYP19A1TBXAS1 | |
| SCHEMBL29834888 | 0.80 | HTR2A (0.65) | POLBMEN1KMT2ATP53HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464604-B1 | 1-Indolylalkyl-4-(alkoxy-pyrimidinyl)piperazines | BRISTOL MYERS SQUIBB CO (US) | 1995-03-29 | — | — | EP | disclosed |
| EP-0464604-A2 | 1-Indolylalkyl-4-(alkoxy-pyrimidinyl)piperazines | Bristol-Myers Squibb Company (US) | 1992-01-08 | — | — | EP | disclosed |
| US-5077293-A | Antidepressants | BRISTOL-MYERS SQUIBB CO. (US) | 1991-12-31 | — | — | US | disclosed |