Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.60 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | SMO | Q99835 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291757 | 0.85 | SMN1; SMN2 (0.70) | SMN1; SMN2HPGDP2RY12USP30HRH3 | |
| SCHEMBL2428493 | 0.83 | P2RY12 (0.72) | SMN1; SMN2HPGDP2RY12USP30HRH3 | |
| SCHEMBL63484 | 0.83 | CKS1B (0.58) | SMN1; SMN2HPGDHRH3RAB9ANPC1 | |
| SCHEMBL7887534 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2HPGDP2RY12USP30HRH3 | |
| SCHEMBL11937854 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2HPGDP2RY12USP30HRH3 | |
| SCHEMBL8931657 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2HPGDP2RY12USP30RAB9A | |
| SCHEMBL1859145 | 0.82 | HRH3 (0.67) | SMN1; SMN2HPGDHRH3RAB9AGAA | |
| SCHEMBL2427846 | 0.81 | P2RY12 (0.62) | SMN1; SMN2HPGDP2RY12USP30HRH3 | |
| SCHEMBL8291092 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDP2RY12USP30HRH3 | |
| SCHEMBL11930058 | 0.81 | SMN1; SMN2 (0.80) | SMN1; SMN2HPGDP2RY12USP30HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2229162-A | — | — | None | — | — | JP | disclosed |
| EP-0385351-B1 | Nicotinic acid derivatives and pharmaceutical compositions comprising same | NISSHIN FLOUR MILLING CO (JP) | 1995-01-11 | — | — | EP | disclosed |
| US-5025012-A | Cardiovascular disorders; antiischemic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-06-18 | — | — | US | disclosed |
| JP-H02229162-A | NICOTINIC ACID OR ITS ESTER DERIVATIVE | NISSHIN FLOUR MILLING CO LTD | 1990-09-11 | — | — | JP | disclosed |
| EP-0385351-A1 | Nicotinic acid derivatives and pharmaceutical compositions comprising same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |