Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 8/20 | 0.51 |
| ▸ | HTR1B | P28222 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25903380 | 0.84 | HTR1D (0.69) | HTR1DHTR1BHTR2AHTR2CHTR1A | |
| SCHEMBL17066884 | 0.83 | HTR1D (0.55) | HTR1DHTR1BHTR2AHTR2CHTR1A | |
| SCHEMBL9200459 | 0.82 | HTR1D (0.49) | HTR1DHTR1BHTR2AHTR2CHTR1A | |
| SCHEMBL22643882 | 0.76 | HTR1D (0.58) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL7755853 | 0.74 | HTR1D (0.73) | HTR1DHTR1BHTR2AHTR2CHTR1A | |
| SCHEMBL266613 | 0.74 | NPSR1 (0.68) | HTR1DHTR1BHTR2AHTR2CHTR1A | |
| SCHEMBL22643951 | 0.72 | HTR1D (0.75) | HTR1DHTR1BHTR2AHTR1A | |
| SCHEMBL7651463 | 0.72 | HTR1D (0.67) | HTR1DHTR1BHTR2AHTR2CHTR1A | |
| SCHEMBL12013054 | 0.72 | HTR1D (0.73) | HTR1DHTR1BHTR1A | |
| SCHEMBL20921203 | 0.72 | TSHR (0.64) | HTR1DHTR1BHTR2AHTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |