Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338876 | 0.90 | SOAT1 (0.35) | SOAT1 | |
| SCHEMBL8339036 | 0.88 | SOAT1 (0.37) | SOAT1 | |
| SCHEMBL8340844 | 0.87 | SOAT1 (0.36) | SOAT1 | |
| SCHEMBL8338866 | 0.86 | SOAT1 (0.41) | SOAT1 | |
| SCHEMBL8344037 | 0.85 | SOAT1 (0.34) | SOAT1 | |
| SCHEMBL8344420 | 0.84 | KMT2A (0.36) | SOAT1 | |
| SCHEMBL8340821 | 0.83 | KMT2A (0.36) | — | |
| SCHEMBL8339510 | 0.83 | SOAT1 (0.39) | SOAT1 | |
| SCHEMBL8344907 | 0.83 | POLB (0.36) | GAAPOLBHTR1AHTR2CHTR2A | |
| SCHEMBL8341284 | 0.82 | SOAT1 (0.38) | SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |