Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | UPP1 | Q16831 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16048098 | 0.88 | KDM4D (0.43) | KDM4DKDM4EPLATHPGDCYP2C19 | |
| SCHEMBL16077819 | 0.85 | HPGD (0.47) | KDM4DKDM4EPLATHPGDCYP2C19 | |
| SCHEMBL16077828 | 0.79 | KDM4E (0.59) | KDM4DKDM4EPLATHPGDCYP2C19 | |
| SCHEMBL16046971 | 0.78 | KDM4D (0.41) | KDM4DKDM4EPLATUPP1HPGD | |
| SCHEMBL5826974 | 0.76 | GAA (0.40) | KDM4EHPGDALDH1A1GAAMAPT | |
| SCHEMBL5826703 | 0.76 | GAA (0.37) | KDM4EALDH1A1GAAMAPTHTT | |
| SCHEMBL9204181 | 0.75 | KDM4E (0.45) | KDM4DKDM4EPLATHPGDKDM5A | |
| SCHEMBL16047451 | 0.74 | KDM4D (0.44) | KDM4DKDM4EPLATHPGDCYP2C19 | |
| SCHEMBL10438610 | 0.73 | KDM4E (0.40) | KDM4EHPGDCYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL16077820 | 0.72 | KDM5A (0.43) | KDM4DKDM4EPLATHPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369145-B1 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEM IND INC (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-4992442-A | Bronchodilator agents | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0369145-A2 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1990-05-23 | — | — | EP | disclosed |