Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 19/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108566 | 0.99 | ALOX5AP (0.75) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9212513 | 0.99 | ALOX5AP (0.74) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9212493 | 0.93 | ALOX5AP (0.76) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2106826 | 0.89 | ALOX5AP (0.78) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2109526 | 0.88 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL9216414 | 0.86 | ALOX5AP (0.78) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL9306842 | 0.86 | ALOX5AP (0.98) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2108496 | 0.85 | ALOX5AP (0.77) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL29372303 | 0.85 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| Quiflapon SCHEMBL30505315 | 0.85 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| WO-1994013293-A2 | (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
| US-5272145-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-12-21 | — | — | US | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |