Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.74 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 12/20 | 0.70 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212605 | 1.00 | PIM1 (0.74) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL9570682 | 0.88 | PIM1 (0.78) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL9570687 | 0.88 | PIM1 (0.78) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL2544390 | 0.87 | PIM1 (0.76) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL2544389 | 0.87 | PIM1 (0.76) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL4852583 | 0.85 | PIM1 (0.74) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL4852574 | 0.85 | PIM1 (0.74) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL9326177 | 0.85 | HPGD (0.80) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL10272939 | 0.85 | PIM1 (0.74) | PIM1PIM2HPGDCISD1MAOA | |
| SCHEMBL9326976 | 0.85 | HPGD (0.80) | PIM1PIM2HPGDCISD1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680472-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995014673-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA S.P.A. (IT) | 1995-06-01 | — | — | WO | disclosed |