Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | ALOX5AP | P20292 | 19/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217250 | 0.92 | PTGS1 (0.53) | PTGS1PTGS2ALOX5APALOX5 | |
| SCHEMBL2107323 | 0.81 | PTGS1 (0.76) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 | |
| SCHEMBL2108367 | 0.78 | ALOX5AP (0.57) | ALOX5AP | |
| SCHEMBL16046913 | 0.78 | ALOX5AP (0.60) | ALOX5AP | |
| SCHEMBL2106748 | 0.78 | PTGS1 (0.93) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 | |
| SCHEMBL15264572 | 0.77 | ALOX5AP (0.57) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 | |
| SCHEMBL2106719 | 0.77 | PTGS1 (0.77) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 | |
| SCHEMBL12356797 | 0.76 | PTGS1 (0.89) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 | |
| SCHEMBL2108178 | 0.76 | PTGS1 (1.00) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 | |
| SCHEMBL2107994 | 0.76 | PTGS1 (0.89) | PTGS1PTGS2ALOX5APCYP3A4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| WO-1994013293-A2 | (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
| US-5272145-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-12-21 | — | — | US | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| EP-0419049-A1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1991-03-27 | — | — | EP | disclosed |