Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 3/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | ADH4 | P08319 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3026715 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL2407509 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL9213041 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL1524661 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL9205907 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL22042636 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL1534018 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL1524591 | 1.00 | TSHR (0.41) | TSHRCYP1A2FAAHTRPV1THRB | |
| SCHEMBL6263591 | 0.98 | CYP1A2 (0.41) | TSHRCYP1A2NAAAEPHX1SIGMAR1 | |
| SCHEMBL22042665 | 0.98 | CYP1A2 (0.41) | TSHRCYP1A2NAAAEPHX1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421441-B1 | Pantothenic acid derivatives | FUJIREBIO KK (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5120738-A | Cardiovascular disorders | FUJIREBIO INC. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0421441-A2 | Pantothenic acid derivatives | FUJIREBIO INC. (JP) | 1991-04-10 | — | — | EP | disclosed |
| EP-0098408-B1 | CATALYST CONTAINING A PHOSPHINE OXIDE MODIFIER AND PROCESS FOR PRODUCTION OF POLYMERS HAVING INCREASED 1,2-MICROSTRUCTURE | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1986-10-29 | — | — | EP | disclosed |