Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 12/20 | 0.62 |
| ▸ | PARP11 | Q9NR21 | 8/20 | 0.62 |
| ▸ | PARP1 | P09874 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29977721 | 0.85 | PARP10 (0.56) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL15830717 | 0.85 | PARP10 (0.56) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL20488275 | 0.85 | PARP10 (0.56) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL23865194 | 0.85 | PARP10 (0.56) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL12559528 | 0.85 | GRM5 (0.59) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL24681318 | 0.85 | PARP10 (0.56) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL15471838 | 0.85 | PARP10 (0.56) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL20884012 | 0.83 | PARP10 (0.53) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL20232210 | 0.83 | PARP10 (0.53) | PARP10PARP11PARP1KDM4EF7 | |
| SCHEMBL18875036 | 0.80 | PARP10 (0.50) | PARP10PARP11PARP1KDM4EF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589625-B1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | LILLY CO ELI (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |