Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | MARK3 | P27448 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | NEK2 | P51955 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.55 |
| ▸ | STK3 | Q13188 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206496 | 0.90 | IKBKB (0.57) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9206517 | 0.89 | IKBKB (0.56) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9206941 | 0.89 | IKBKB (0.56) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9207964 | 0.89 | IKBKB (0.56) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9215285 | 0.88 | IKBKB (0.55) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9215159 | 0.84 | PIM1 (0.56) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9211587 | 0.84 | IKBKB (0.54) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9215430 | 0.83 | IKBKB (0.53) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9738915 | 0.83 | IKBKB (0.54) | IKBKBAURKACHUKMAPK13DAPK3 | |
| SCHEMBL9207531 | 0.83 | IKBKB (0.39) | IKBKBAURKACHUKMAPK13DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424802-B1 | Tricyclic quinoline antineoplastic agents | ABBOTT LAB (US) | 1995-12-20 | — | — | EP | claimed |
| EP-0424802-A2 | Tricyclic quinoline antineoplastic agents | ABBOTT LABORATORIES (US) | 1991-05-02 | — | — | EP | claimed |
| EP-0424802-B1 | Tricyclic quinoline antineoplastic agents | ABBOTT LAB (US) | 1995-12-20 | — | — | EP | disclosed |
| US-5071848-A | TRICYCLIC QUINOLINE ANTINEOPLASTIC AGENTS | ABBOTT LABORATORIES (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0424802-A2 | Tricyclic quinoline antineoplastic agents | ABBOTT LABORATORIES (US) | 1991-05-02 | — | — | EP | disclosed |