Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213981 | 0.84 | KMT2A (0.39) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9203897 | 0.81 | KMT2A (0.37) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9208837 | 0.81 | MEN1 (0.37) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9212739 | 0.80 | MEN1 (0.35) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9211058 | 0.80 | CACNA1C (0.38) | KMT2AMEN1CYP2C9CYP2C19MAPT | |
| SCHEMBL9209067 | 0.79 | MEN1 (0.52) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9272410 | 0.79 | MEN1 (0.35) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9208945 | 0.78 | MAPT (0.37) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9208636 | 0.76 | MEN1 (0.36) | KMT2AMEN1CYP2C9ALOX15CYP2C19 | |
| SCHEMBL9205054 | 0.76 | MEN1 (0.38) | KMT2AMEN1CYP2C9ALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506434-B1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | SANKYO CO (JP) | 1995-02-22 | — | — | EP | disclosed |
| US-5356918-A | Oxazolidinone compounds and method of using the same as a vasodilator | SANKYO COMPANY, LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| US-5298516-A | Treatment of cardiovascular disorders, angina | SANKYO COMPANY, LIMITED (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0506434-A1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | Sankyo Company Limited (JP) | 1992-09-30 | — | — | EP | disclosed |