Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208130 | 0.99 | HRH3 (0.44) | HRH3GRM5MCHR1SIGMAR1PRMT5 | |
| Hydrochloric Acid SCHEMBL9216849 | 0.96 | HRH3 (0.42) | HRH3GRM5MCHR1SIGMAR1PRMT5 | |
| SCHEMBL9212953 | 0.90 | MEN1 (0.41) | HRH3MCHR1SIGMAR1SLC6A4 | |
| Hydrochloric Acid SCHEMBL9207896 | 0.89 | MEN1 (0.42) | MCHR1SIGMAR1SLC6A4 | |
| SCHEMBL9215610 | 0.87 | MEN1 (0.43) | MCHR1SLC6A4 | |
| SCHEMBL9213420 | 0.86 | HRH3 (0.46) | HRH3GRM5SIGMAR1PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9213083 | 0.85 | MEN1 (0.44) | HRH3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9209655 | 0.85 | GRM5 (0.39) | HRH3GRM5SIGMAR1SLC6A4 | |
| SCHEMBL9212473 | 0.85 | KMT2A (0.40) | SLC6A4 | |
| Hydrochloric Acid SCHEMBL9214727 | 0.84 | KDM2B (0.39) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |