Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.56 |
| ▸ | ATIC | P31939 | 4/20 | 0.54 |
| ▸ | DHFR | P00374 | 5/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210960 | 1.00 | GART (0.56) | GARTATICDHFRTYMS | |
| SCHEMBL9207767 | 1.00 | GART (0.56) | GARTATICDHFRTYMS | |
| SCHEMBL9210939 | 1.00 | GART (0.56) | GARTATICDHFRTYMS | |
| SCHEMBL9215589 | 0.95 | GART (0.50) | GARTATICDHFRTYMS | |
| SCHEMBL9219680 | 0.95 | GART (0.50) | GARTATICDHFRTYMS | |
| SCHEMBL9263123 | 0.87 | GART (0.63) | GARTATICDHFRTYMS | |
| SCHEMBL9207703 | 0.86 | GART (0.60) | GARTATICDHFRTYMS | |
| SCHEMBL9211691 | 0.86 | GART (0.60) | GARTATICDHFRTYMS | |
| SCHEMBL9211704 | 0.86 | GART (0.60) | GARTATICDHFRTYMS | |
| SCHEMBL9216180 | 0.86 | GART (0.60) | GARTATICDHFRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344922-B1 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | UNIV PRINCETON (US) | 1995-10-18 | — | — | EP | claimed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | claimed |