Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214015 | 0.78 | HRH3 (0.65) | KCNH2HRH3LTA4HACKR3 | |
| SCHEMBL9219081 | 0.73 | KCNH2 (0.41) | KCNH2HRH3KDM4EALDH1A1MAPT | |
| SCHEMBL9219781 | 0.72 | HRH3 (0.50) | KCNH2HRH3LTA4HACKR3PANK3 | |
| SCHEMBL9211253 | 0.67 | HRH3 (0.65) | KCNH2HRH3LTA4HACKR3 | |
| SCHEMBL9211677 | 0.67 | HRH3 (0.65) | KCNH2HRH3LTA4HACKR3 | |
| SCHEMBL9216760 | 0.65 | HRH3 (0.61) | KCNH2HRH3LTA4HACKR3CYP1A2 | |
| SCHEMBL9311956 | 0.64 | CYP1A2 (0.43) | CYP1A2BPTFALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9213571 | 0.64 | HRH3 (0.65) | KCNH2HRH3LTA4HACKR3KDM4E | |
| SCHEMBL9668080 | 0.63 | HRH3 (0.68) | KCNH2HRH3LTA4HACKR3KDM4E | |
| SCHEMBL9217275 | 0.63 | HRH3 (0.65) | KCNH2HRH3LTA4HACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320032-B1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-01-18 | — | — | EP | disclosed |
| US-5231184-A | Viricide intermediate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-27 | — | — | US | disclosed |
| US-5106973-A | Viricide intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-21 | — | — | US | disclosed |
| US-4992433-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-12 | — | — | US | disclosed |