Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.59 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 12/20 | 0.53 |
| ▸ | DRD2 | P14416 | 9/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211095 | 0.89 | PLK1 (0.49) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL9216167 | 0.87 | PLK1 (0.47) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL9533936 | 0.82 | PLK1 (0.74) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL8335825 | 0.81 | — | — | |
| SCHEMBL7959083 | 0.77 | PLK1 (0.50) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL23654152 | 0.75 | PLK1 (0.53) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL20673855 | 0.75 | PLK1 (0.53) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL20430016 | 0.75 | PLK1 (0.53) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL21614870 | 0.74 | DRD4 (0.51) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL19154256 | 0.74 | PLK1 (0.53) | PLK1CSNK2A1PLK3DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |