Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.68 |
| ▸ | ALOX5AP | P20292 | 17/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | RECQL | P46063 | 3/20 | 0.54 |
| ▸ | BLM | P54132 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044180 | 0.92 | PTGES2 (0.80) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL13415384 | 0.92 | PTGES2 (0.68) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL9261333 | 0.89 | ALOX5AP (0.67) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL13415379 | 0.84 | ALOX5AP (0.68) | ALOX5AP | |
| SCHEMBL12014953 | 0.84 | PTGES2 (0.57) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL167199 | 0.83 | PTGES2 (0.66) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL176187 | 0.82 | PTGES2 (0.56) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL10264786 | 0.82 | PTGES2 (0.56) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL13415383 | 0.82 | PTGES2 (0.67) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 | |
| SCHEMBL9044184 | 0.82 | PTGES2 (0.78) | PTGES2ALOX5APALOX5CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |