Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219757 | 0.94 | TP53 (0.63) | TP53SMN1; SMN2ALDH1A1POLBTHRB | |
| SCHEMBL9212126 | 0.93 | TP53 (0.56) | TP53SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL9213606 | 0.92 | SMN1; SMN2 (0.56) | TP53SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL9217396 | 0.91 | TP53 (0.71) | TP53SMN1; SMN2ALDH1A1POLBTHRB | |
| SCHEMBL9430659 | 0.89 | POLB (0.60) | TP53SMN1; SMN2ALDH1A1POLBTHRB | |
| SCHEMBL9221106 | 0.89 | POLB (0.60) | TP53SMN1; SMN2ALDH1A1POLBTHRB | |
| SCHEMBL9430836 | 0.88 | TP53 (0.56) | TP53SMN1; SMN2ALDH1A1POLBTHRB | |
| SCHEMBL9216793 | 0.88 | POLB (0.58) | TP53SMN1; SMN2ALDH1A1POLBTHRB | |
| SCHEMBL9216897 | 0.87 | TP53 (0.63) | TP53SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL9431339 | 0.85 | POLB (0.66) | TP53SMN1; SMN2ALDH1A1POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |