SCHEMBL9218889

SCHEMBL9218889

COc1ccc2c(c1)CN(C(=O)CBr)CCS2

nearest known ligand 0.82

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RYR2 Q92736 19/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL629999 0.91 RYR2 (0.86) RYR2
SCHEMBL6867475 0.90 RYR2 (0.86) RYR2
SCHEMBL806609 0.90 RYR2 (1.00) RYR2
SCHEMBL12265307 0.90 RYR2 (0.88) RYR2
SCHEMBL6867184 0.89 RYR2 (0.84) RYR2
SCHEMBL6883445 0.88 RYR2 (0.82) RYR2
SCHEMBL26345148 0.88 RYR2 (0.82) RYR2
SCHEMBL6866697 0.88 RYR2 (1.00) RYR2
SCHEMBL807017 0.87 RYR2 (1.00) RYR2
SCHEMBL12894368 0.87 RYR2 (0.88) RYR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0565721-B1 1,4-BENZOTHIAZEPINE DERIVATIVE KANEKO NOBORU (JP) 1995-07-26 EP disclosed
US-5416066-A FOR THE PREVENTION OF MYOCARDIAL INFARCTION OR INHIBITING MYOCARDIAL NECROSIS KIRIN BREWERY CO., LTD. (JP) 1995-05-16 US disclosed
EP-0565721-A1 1,4-BENZOTHIAZEPINE DERIVATIVE KANEKO, Noboru (JP) 1993-10-20 EP disclosed